GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9457247 | 1 | rs2769354 | chr6:167379771 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.62 | 5.18E-6 | Crohn's disease |
| BLCA | cis | rs30187 | 1 | rs27710 | chr5:96126197 | ERAP1 | chr5:96096515-96149837:- | 0.47 | 10.15 | 1.39E-21 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs27710 | chr5:96126197 | ERAP2 | chr5:96211644-96255398:+ | -0.31 | -5.15 | 4.13E-7 | Ankylosing spondylitis |
| BLCA | cis | rs7611238 | 1 | rs2791603 | chr3:195142939 | C3orf21 | chr3:194789015-194991895:- | -0.28 | -5.36 | 1.47E-7 | Body mass index |
| BLCA | cis | rs7655841 | 1 | rs280603 | chr4:129915063 | C4orf33 | chr4:130014829-130033842:+ | -0.31 | -5.12 | 4.83E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs280604 | chr4:129921170 | C4orf33 | chr4:130014829-130033842:+ | -0.32 | -5.31 | 1.83E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs73201462 | 1 | rs2811381 | chr3:127997912 | EEFSEC | chr3:127872313-128127488:+ | 0.37 | 3.93 | 9.91E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs73201462 | 1 | rs2811526 | chr3:127995718 | EEFSEC | chr3:127872313-128127488:+ | 0.34 | 3.86 | 0.000132 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs73201462 | 1 | rs2811527 | chr3:127994604 | EEFSEC | chr3:127872313-128127488:+ | 0.34 | 3.86 | 0.000132 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs73201462 | 1 | rs2811528 | chr3:127994436 | EEFSEC | chr3:127872313-128127488:+ | 0.37 | 3.93 | 9.91E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs73201462 | 1 | rs2811530 | chr3:127993166 | EEFSEC | chr3:127872313-128127488:+ | 0.36 | 3.88 | 0.000122 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| BLCA | cis | rs1577917 | 1 | rs2812972 | chr6:86669880 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -9.82 | 1.86E-20 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs2816815 | chr6:86691656 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -9.95 | 6.51E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs2816821 | chr6:86657084 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10.04 | 3.3E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs2832077 | 1 | rs2832065 | chr21:30135362 | N6AMT1 | chr21:30244513-30257693:- | -0.29 | -4.78 | 2.5E-6 | Cognitive test performance |